Omega Wellness


Excipients



 

Overview

Excipients are inert substances used in the manufacturing of supplements. They are used to give consistency or form for tableting. Vitamin tablets cannot be manufactured without excipients; they ensure quality control in the tablet manufacturing process. Tablet excipients help ensure that the bulk powder flows smoothly through the equipment, and that the tablets are of the right consistency so they will break down in the body as predicted. Tableting is a combination of science and art; it takes years of experience to master the tableting process. Some of the common excipients include binders, fillers, lubricants, and disintegrants.

Binders
Binders hold tablets together and prevent breakage. Binders are substances that give cohesive qualities to powdered materials; they hold the ingredients together for tablet formulation. A common binder is cellulose.

Fillers
Fillers allow tableting of small amounts of nutrients to be large enough to manufacture. Also, fillers are inert materials added to the tablets to increase their bulk, in order to make them fit a particular size tablet mold for compression. Some common fillers are calcium phosphate and cellulose.

Lubricants
Lubricants allow tablets to be ejected from its mold without fracture. Lubricants are inert material added in very small amounts (usually less than 1%) to the powder blend to prevent the compressed tablet from sticking to the tablet punches and dies. Common lubricants include vegetable stearins (similar to vegetable shortening), stearic acid, and magnesium stearate.

Disintegrants
Disintegrants help the product to break up inside the digestive tract. They are added to the formulation to help the tablet disintegrate after consumption, thereby releasing the active ingredients. Common disintegrants include several modified cellulose derivatives, which work by swelling when wet.

Emulsifiers
Emulsifiers are surface-active agents that promote the formation and stabilization of an emulsion. An emulsifier also helps to keep raw materials used in the formulation in suspension.

Coating
Coating allows for easier swallowing, prevents powdering, masks odor and offensive tastes, and enhances stability and freshness.

Flavors and Sweeteners
Flavors and sweeteners are used to increase the palatability of certain supplements; these are used especially in chewables and sublinguals.

 

Below is a list of the excipients used in our vitamins and dietary supplements.

 

 

 

 

 

Excipient

Use

What is it?

Safety

acacia gum, AKA

used as a binder, sometimes also

plant derived, it is a complex and

widely used in foods

gum arabic

used as a granulating agent or a filler;

variable mixture of arabinogalactan

 

 

used to help suspend the insoluble

oligosaccharides, polysaccharides

 

 

ingredients in a formulation

and glycoproteins

 

calcium stearate

helps to ensure that ingredients flow

mineral calcium with stearic acid,

widely used in foods;

 

smoothly during manufacture; may be

which is a fatty acid that is derived

GRAS* status

 

used as an emulsifier

from vegetable fats

 

carob

a low fat alternative to cocoa powder,

derived from the pod of locust bean (a

widely used in health

 

used as flavoring; also used to color

tropical tree)

foods

 

softgels (particularly flax softgels),

 

 

 

the purpose for this is to protect

 

 

 

active ingredients from light

 

 

cellulose capsule

2-piece hard-shelled capsule that

derived from wood pulp

widely used in nutritional

(veggie-cap)

contains mixed powders; vegetarian

 

supplement industry;

 

alternative to gelatin capsule

 

GRAS status

citric acid

used to help protect flavors in

derived from citrus foods

safe as food

 

chewables

 

 

croscarmellose

helps ensure that the tablet will be

modified cellulose gum, cellulose is

regarded as a non-toxic

sodium

able to disintegrate during digestion;

plant fiber

and non-irritant material

 

helps to ensure proper absorption

 

 

dicalcium

used to hold tablets together, ensures

inert mineral composed of calcium

widely used in foods;

phosphate,

that the tablet does not break apart

and phosphate; occurs in nature

GRAS status

tricalcium

in the bottle; sometimes used as a

 

 

phosphate

source of calcium or phosphorus

 

 

ethylcellulose

helps to improve the stability of a

fiber taken from a plant source

widely used in foods;

 

formulation; sometimes used to mask

 

GRAS status

 

the taste of a tablet

 

 

food glaze

used for coating tablets

vegetable derived

widely used in foods

fructose

used as a sweetener; absorbs more

a simple sugar that occurs naturally in

naturally occurring in

 

slowly from the GI tract than sucrose

fruits (a monosaccharide)

fruits and honey

 

(table sugar)

 

 

gelatin

used for forming capsules and

purified protein taken from animal

widely used in foods

 

softgels

collagen

 

glycerin

serves as a preservative, may be

occurs naturally in fats and oils

widely used in foods;

 

added to provide moisture to a

 

GRAS status; normally

 

product; also can be used to provide a

 

consumed in the diet

 

sweet flavor

 

 

glyceryl

helps ensure that the ingredients flow

substance derived from fatty acids of

widely used in foods

monostearate

smoothly during manufacture, can

plants

 

 

be used as a coating to promote the

 

 

 

stability of the product; also used to

 

 

 

improve texture

 

 

glycine

an amino acid sometimes used as a

isolated from gelatin

safe as food

 

filler for tableting

 

 

guar gum

used as a thickener and stabilizer,

gum derived from the seeds of

widely used in foods

 

sometimes used as a binder; also

the guar plant, a natural polymer

 

 

used as a source of dietary fiber

composed of units of sugar

 

gum arabic

used as a binder, sometimes also

plant derived, it is a complex and

widely used in foods

 

used as a granulating agent or a filler

variable mixture of arabinogalactan

 

 

 

oligosaccharides, polysaccharides

 

 

 

and glycoproteins

 

hydroxypropyl

used to coat tablets, ensuring stability

fiber derived from a plant source

widely used in foods

methylcellulose

 

 

 

magnesium

used to help ensure that the

a combination of the mineral

widely used in foods;

stearate

ingredients flow smoothly during

magnesium and stearic acid, a fat

GRAS status

 

manufacturing

found in vegetables

 

maltodextrin

used during manufacture to help

a non-fermentable sugar obtained

GRAS status

 

ensure that ingredients flow smoothly;

from corn starch

 

 

may be used to help stabilize a

 

 

 

product; can serve as a thickener or

 

 

 

improve texture; used as a nutritive

 

 

 

sweetener

 

 

microcrystalline

often used to hold a tablet together;

a fiber derived from plant sources that

GRAS status

cellulose

ensures that the tablet does not break

has increased water solubility

 

 

apart in the bottle; may also be used

 

 

 

to help ensure that the tablet will be

 

 

 

able to disintegrate during digestion

 

 

 

(helps to ensure proper absorption)

 

 

natural colors (beet

used to enhance colors of

beet juice—juice of beets

safe as food

juice, turmeric,

supplements

turmeric—spice

 

caramel, carob)

 

caramel—caramelized sugar

 

 

 

carob--bean

 

natural flavors

used to enhance the palatability of

fruit powders

safe as food

(orange, cherry,

supplements (chewables), also

 

 

papaya, raspberry,

used as a masking agent

 

 

vanilla, chocolate)

 

 

 

pectin

as both a thickener and an additional

polysaccharide derived from citrus

safe as food

 

source of fiber

peels

 

protein hydrolysate

digestive protein

derived from protein

safe as food

rice powder, rice

used as filler

gluten-free flour milled from rice

safe as food

bran

 

 

 

silicon dioxide

can help ensure that the ingredients

naturally occurring form of the

GRAS status

 

don’t get too sticky; used sometimes

mineral silica

 

 

as a flavor; can be used as an

 

 

 

emulsifier; can also be used for

 

 

 

adding moisture to certain products

 

 

sorbitol

used as a sweetener or a sugar

a sugar alcohol; half as sweet as

widely used in prepared

 

substitute; may also be used to

sugar

diabetic foods: GRAS

 

provide moisture to a product

 

status

stearic acid

used as an emulsifier or a sugar

a fatty acid derived from vegetable

widely used in foods;

 

substitute; may also be used to

fats

GRAS status

 

help ensure that the ingredients

 

 

 

flow smoothly during manufacture;

 

 

 

sometimes used as a flavoring.

 

 

sweeteners

used to enhance the palatability of

various food sources

safe as food

(fructose, honey,

supplements (chewables), also used

 

 

maple crystals,

as a masking agent

 

 

molasses, sucrose,

 

 

 

sugar)

 

 

 

vegetable oils

used in the manufacturing of softgels

vegetable oil

safe as food

(olive & sunflower)

as a filler

 

 

xanthan gum

used to help stabilize a product; also

polysaccharide (complex sugar)

used in foods; GRAS

 

may be used as an emulsifier

produced through fermentation and

status

 

 

purification of a carbohydrate

 

 

*GRAS = generally recognized as safe

 

These statements have not been evaluated by the Food and Drug Administration. This information is not intended to diagnose, treat, imply cure or prevent any disease. For more information regarding excipients, please refer to the excipient list.

FOR EDUCATIONAL PURPOSES ONLY
 
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